Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.

doi:10.1038/s41375-020-0806-0

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Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.

Leukemia - 1 Dec 2020

Herold Tobias, Rothenberg-Thurley Maja, Grunwald Victoria V, Janke Hanna, Goerlich Dennis, Sauerland Maria C, Konstandin Nikola P, Dufour Annika, Schneider Stephanie, Neusser Michaela, Ksienzyk Bianka, Greif Philipp A, Subklewe Marion, Faldum Andreas, Bohlander Stefan K, Braess Jan, Wörmann Bernhard, Krug Utz, Berdel Wolfgang E, Hiddemann Wolfgang, Spiekermann Karsten, Metzeler Klaus H

Abstract excerpt

The revised 2017 European LeukemiaNet (ELN) recommendations for genetic risk stratification of acute myeloid leukemia have been widely adopted, but have not yet been validated in large cohorts of AML patients. We studied 1116 newly diagnosed AML patients (age range, 18-86 years) who had received induction chemotherapy. Among 771 patients not selected by genetics, the ELN-2017 classification re-assigned 26.5% of...

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PMID: 32231256
DOI: 10.1038/s41375-020-0806-0
PMCID: PMC7685975

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