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Integrative analysis of epigenetic subtypes in acute myeloid Leukemia: A multi-center study combining machine learning for prognostic and therapeutic insights

28 May 2025

Abstract excerpt

BACKGROUND: Acute Myeloid Leukemia (AML) exhibits significant heterogeneity in clinical outcomes, yet current prognostic stratification systems based on genetic alterations alone cannot fully capture this complexity. This study aimed to develop an integrated epigenetic-based classification system and evaluate its prognostic value. METHODS: We performed multi-omics analysis on five independent cohorts totaling...

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PMID: 40435135
DOI: 10.1371/journal.pone.0324380

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