Article
A precision medicine classification for treatment of acute myeloid leukemia in older patients.
Journal of hematology & oncology - 23 Jun 2021
Mims Alice S, Kohlschmidt Jessica, Borate Uma, Blachly James S, Orwick Shelley, Eisfeld Ann-Kathrin, Papaioannou Dimitrios, Nicolet Deedra, Mrόzek Krzysztof, Stein Eytan, Bhatnagar Bhavana, Stone Richard M, Kolitz Jonathan E, Wang Eunice S, Powell Bayard L, Burd Amy, Levine Ross L, Druker Brian J, Bloomfield Clara D, Byrd John C
Abstract excerpt
BACKGROUND: Older patients (≥ 60 years) with acute myeloid leukemia (AML) often have multiple, sequentially acquired, somatic mutations that drive leukemogenesis and are associated with poor outcome. Beat AML is a Leukemia and Lymphoma Society-sponsored, multicenter umbrella study that algorithmically segregates AML patients based upon cytogenetic and dominant molecular abnormalities (variant allele frequencies...
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