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IL-6/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization

1 Feb 2023

Abstract excerpt

Type I interferons (IFN-Is) have been harnessed for cancer therapies due to their immunostimulatory functions. However, certain tumor-tolerating activities by IFN-Is also exist, and may potentially thwart their therapeutic effects. In this respect, our previous studies have demonstrated a monocyte-orchestrated, IFN-I-to-IL-4 cytokine axis, which can subsequently drive M2-skewed pro-tumoral polarization of...

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PMID: 36726024
DOI: 10.1038/s41598-022-23721-9

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