BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.

doi:10.1084/jem.20190711

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Article

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.

The Journal of experimental medicine - 7 Sept 2020

Grant Francis M, Yang Jie, Nasrallah Rabab, Clarke James, Sadiyah Firas, Whiteside Sarah K, Imianowski Charlotte J, Kuo Paula, Vardaka Panagiota, Todorov Tihomir, Zandhuis Nordin, Patrascan Ilinca, Tough David F, Kometani Kohei, Eil Robert, Kurosaki Tomohiro, Okkenhaug Klaus, Roychoudhuri Rahul

Abstract excerpt

Regulatory T (Treg) cell populations are composed of functionally quiescent resting Treg (rTreg) cells which differentiate into activated Treg (aTreg) cells upon antigen stimulation. How rTreg cells remain quiescent despite chronic exposure to cognate self- and foreign antigens is unclear. The transcription factor BACH2 is critical for early Treg lineage specification, but its function following lineage...

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Identifiers

PMID: 32515782
DOI: 10.1084/jem.20190711
PMCID: PMC7478731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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