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Article

The transcription factor BACH2 promotes tumor immunosuppression

4 Jan 2016

Abstract excerpt

The immune system has a powerful ability to recognize and kill cancer cells, but its function is often suppressed within tumors, preventing clearance of disease. Functionally diverse innate and adaptive cellular lineages either drive or constrain immune reactions within tumors. The transcription factor (TF) BACH2 regulates the differentiation of multiple innate and adaptive cellular lineages, but its role in...

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PMID: 26731475
DOI: 10.1172/jci82884

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