Article
Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.
Blood - 21 Jan 2010
Feng Xiaoming, Ippolito Gregory C, Tian Lifeng, Wiehagen Karla, Oh Soyoung, Sambandam Arivazhagan, Willen Jessica, Bunte Ralph M, Maika Shanna D, Harriss June V, Caton Andrew J, Bhandoola Avinash, Tucker Philip W, Hu Hui
Abstract excerpt
Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.