Article
d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Biochimica et biophysica acta. Proteins and proteomics - 1 Sept 2020
Shimizu Yukiko, Ishii Chiharu, Yanobu-Takanashi Rieko, Nakano Kenta, Imaike Akio, Mita Masashi, Hamase Kenji, Okamura Tadashi
Abstract excerpt
d-Amino acids, enantiomers of l-amino acids, are increasingly recognized as physiologically active molecules as well as potential biomarkers for diseases. d-Amino acid oxidase (DAO) catalyzes the oxidative deamination of d-amino acids and is present in a wide variety of organisms from yeasts to humans. Previous studies indicated that LEA rats lacked DAO activity, and levels of d-Ser and d-Ala were markedly...
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