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Genetic polymorphism of aldehyde oxidase in Donryu rats.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2007

Itoh Kunio, Masubuchi Akiko, Sasaki Takamitsu, Adachi Mayuko, Watanabe Nobuaki, Nagata Kiyoshi, Yamazoe Yasushi, Hiratsuka Masahiro, Mizugaki Michinao, Tanaka Yorihisa

Abstract excerpt

One of major metabolic pathways of [(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine] (RS-8359), a selective and reversible monoamine oxidase type A inhibitor, is the aldehyde oxidase-catalyzed 2-hydroxylation at the pyrimidine ring. Donryu rats showed a dimorphic pattern for the 2-oxidation activity with about 20- to 40-fold variations in the Vmax/Km values between a low and a high...

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PMID: 17293383
DOI: 10.1124/dmd.106.011502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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