Article
Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography.
Indian journal of pharmacology - 1 Jul 2026
Magar Vidya Kishanrao, Khavane Karna, Wagh Anita, Shelke Santosh, Padul Rashmi, Dudhane Shradha
Abstract excerpt
ABSTRACT: The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase that plays a central role in regulating cell growth, differentiation, and survival. In non-small cell lung cancer (NSCLC) and several other malignancies, activating mutations within the EGFR kinase d...
Topics
- Humans
- ErbB Receptors
- Antineoplastic Agents
- Crystallography, X-Ray
- Protein Kinase Inhibitors
- Animals
- Mutation
- Neoplasms
- Drug Resistance, Neoplasm