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Article

Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography.

Indian journal of pharmacology - 1 Jul 2026

Magar Vidya Kishanrao, Khavane Karna, Wagh Anita, Shelke Santosh, Padul Rashmi, Dudhane Shradha

Abstract excerpt

ABSTRACT: The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase that plays a central role in regulating cell growth, differentiation, and survival. In non-small cell lung cancer (NSCLC) and several other malignancies, activating mutations within the EGFR kinase domain lead to persistent receptor activation and uncontrolled downstream signalling. Over the past two decades, X-ray...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42583967
DOI: 10.4103/ijp.ijp_1341_25
PMCID: PMC13412494

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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