Article

A Molecular Dynamics Protocol for Rapid Prediction of EGFR Overactivation and Its Application to the Rare Mutations S768I, S768N, D761N

2025-03-05

Abstract excerpt

Hyperactivation caused by mutations in the Epidermal Growth Factor Receptor (EGFR) kinase domain is implicated in various diseases, including cancer. However, the structural mechanisms underlying overactivation in many EGFR mutations remain poorly understood, and exploring these mechanisms through conventional experiments or in silico simulations is often labor- and cost-intensive. Here, we establish a Molecular...

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Literature Corpus work: 7f214d07-b913-5f67-9701-daa6d0d9dac2
DOI: 10.1101/2025.02.27.640703

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