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Article

Mechanism of drug efficacy within the EGF receptor revealed by microsecond molecular dynamics simulation.

Molecular cancer therapeutics - 1 Nov 2012

Wan Shunzhou, Wright David W, Coveney Peter V

Abstract excerpt

The EGF receptor (EGFR) regulates important cellular processes including proliferation, differentiation, and apoptosis. EGFR is frequently overexpressed in a range of cancers and is associated with disease progression and treatment. Clinical studies have shown that EGFR mutations confer tumor sensitivity to tyrosine kinase inhibitors in patients with non-small cell lung cancer. In this study, we have conducted...

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Identifiers

PMID: 22863610
DOI: 10.1158/1535-7163.MCT-12-0644-T

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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