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Article

Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy.

The Journal of biological chemistry - 28 Mar 2008

Lavery Gareth G, Walker Elizabeth A, Turan Nil, Rogoff Daniela, Ryder Jeffery W, Shelton John M, Richardson James A, Falciani Francesco, White Perrin C, Stewart Paul M, Parker Keith L, McMillan Daniel R

Abstract excerpt

Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver H6PD is required for the 11-oxoreductase activity of 11beta-hydroxysteroid dehydrogenase type 1, which converts inactive 11-oxo-glucocorticoids to their active 11-hydroxyl counterparts; consequently, H6PD null mice are relatively...

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Identifiers

PMID: 18222920
DOI: 10.1074/jbc.M710067200
PMCID: PMC2417187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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