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Conversion of human fibroblasts into functional cardiomyocytes by small molecules

29 Apr 2016

Abstract excerpt

Reprogramming somatic fibroblasts into alternative lineages would provide a promising source of cells for regenerative therapy. However, transdifferentiating human cells into specific homogeneous, functional cell types is challenging. Here we show that cardiomyocyte-like cells can be generated by treating human fibroblasts with a combination of nine compounds that we term 9C. The chemically induced...

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PMID: 27127239
DOI: 10.1126/science.aaf1502

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