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Article

Association of +138I/D and Lys198Asn Polymorphisms in the Endothelin-1 Gene with Early Onset of Coronary Artery Disease among the Chinese Han Population.

Medical science monitor : international medical journal of experimental and clinical research - 5 Jun 2020

Tu Guosheng, Fang Zhengxu, Zhao Yu, Wu Qinghua

Abstract excerpt

BACKGROUND Human endothelin-1 (ET-1) gene polymorphism is closely associated with coronary artery disease (CAD). This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ET-1 protein expression upon stimulation with pro-inflammatory...

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PMID: 32499477
DOI: 10.12659/MSM.921542
PMCID: PMC7297021

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