Article
Endothelin-converting enzyme-1b C-338A polymorphism is associated with the increased risk of coronary artery disease in Chinese population.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2007
Wang Lian-Sheng, Tang Na-Ping, Zhu Huai-Jun, Zhou Bo, Yang Li, Wang Bin
Abstract excerpt
BACKGROUND: Endothelin-converting enzyme-1 (ECE-1), the key enzyme responsible for endothelin-1 generation, has been linked to coronary artery disease (CAD). Recently, a genetic polymorphism (ECE-1b C-338A) located in ECE-1 gene promoter was identified. However, it is unclear whether this polymorphism is associated with the risk of CAD. METHODS: We conducted a study with CAD patients and controls matched by age...
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