Article
A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
Molecular biology reports - 1 May 2009
Chen Zhong, Qian Qi, Ma Genshan, Wang Jiahong, Zhang Xiaoli, Feng Yi, Shen Chengxing, Yao Yuyu
Abstract excerpt
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis >or=50% or previous myocardial...
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