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Expression profile of apolipoproteins (APOE) and endothelin-1 (ET-1) genes in ischemic heart disease.

BMC cardiovascular disorders - 1 Jun 2026

Sharif Saima, Saqib Muhammad, Rafaqat Saira, Anum Laaiba, Cojic Milena, Klisic Aleksandra

Abstract excerpt

Ischemic heart disease (IHD) remains a leading cause of morbidity and mortality worldwide, characterized by atherosclerosis and functional alterations in coronary circulation. Endothelin (ET-1), a potent vasoconstrictor, is implicated in coronary artery vasoconstriction, myocardial ischemia, and atherosclerosis through its mitogenic effects. The APOE is associated with increased LDL cholesterol, triglycerides,...

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Apolipoproteins E
Case-Control Studies
Endothelin-1
APOE gene
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Myocardial Ischemia

Real-Time Polymerase Chain Reaction

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Identifiers

PMID: 42226116
DOI: 10.1186/s12872-026-06056-5
PMCID: PMC13440145

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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