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Article

Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs.

Life sciences - 1 Sept 2020

Zhou Xianwu, Cheng Jiancheng, Chen Zerui, Li Huadong, Chen Shu, Xu Fei, Fan Ruixin, Zhuang Jian, Sun Tucheng

Abstract excerpt

AIMS: Angiotensin II (Ang II) induces aortic dissection (AD) via regulation of pathological changes in vascular smooth muscle cells (VSMCs). However, the molecular mechanisms involved are not fully understood. The aim of this study was to evaluate the potential role of the proto-oncogene non-receptor cellular Abelson tyrosine kinase (c-Abl) in Ang II-induced VSMC phenotypic transformation and apoptosis. MAIN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32497633
DOI: 10.1016/j.lfs.2020.117882

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