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Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis

10 Jun 2008

Abstract excerpt

Severe congenital neutropenia (SCN) was first described just over 50 years ago. The progress in elucidating the clinical features and molecular pathophysiology of SCN closely parallels the progressive growth in our understanding of myelopoiesis. In this historical review, I have delineated this parallel progression in our understanding of the processes of granulocyte differentiation and the pathogenesis of...

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PMID: 18544696
DOI: 10.1182/blood-2007-10-077396

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