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Article

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.

PloS one - 1 Jan 2018

Geissler Sven, Textor Martin, Stumpp Sabine, Seitz Sebastian, Lekaj Anja, Brunk Sabrina, Klaassen Sabine, Schinke Thorsten, Klein Christoph, Mundlos Stefan, Kornak Uwe, Kühnisch Jirko

Abstract excerpt

Gfi1 is a key molecule in hematopoietic lineage development and mutations in GFI1 cause severe congenital neutropenia (SCN). Neutropenia is associated with low bone mass, but the underlying mechanisms are poorly characterized. Using Gfi1 knock-out mice (Gfi1-ko/ko) as SCN model, we studied the relationship between neutropenia and bone mass upon different pathogen load conditions. Our analysis reveals that...

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Identifiers

PMID: 29879182
DOI: 10.1371/journal.pone.0198510
PMCID: PMC5991660

Genes

GFI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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