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Article

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.

Acta neuropathologica communications - 3 Jun 2020

Huang Ting-Ting, Smith Ruben, Bacos Karl, Song Dong-Yan, Faull Richard M, Waldvogel Henry J, Li Jia-Yi

Abstract excerpt

Prominent features of HD neuropathology are the intranuclear and cytoplasmic inclusions of huntingtin and striatal and cortical neuronal cell death. Recently, synaptic defects have been reported on HD-related studies, including impairment of neurotransmitter release and alterations of synaptic components. However, the definite characteristics of synapse dysfunction and the underlying mechanisms remain largely...

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Identifiers

PMID: 32493491
DOI: 10.1186/s40478-020-00949-y
PMCID: PMC7268643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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