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Article

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease

12 Oct 2015

Abstract excerpt

Cognitive dysfunction is an early clinical hallmark of Huntington's disease (HD) preceding the appearance of motor symptoms by several years. Neuronal dysfunction and altered corticostriatal connectivity have been postulated to be fundamental to explain these early disturbances. However, no treatments to attenuate cognitive changes have been successful: the reason may rely on the idea that the temporal sequence...

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PMID: 26464483
DOI: 10.1093/hmg/ddv426

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