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Article

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis.

Nature communications - 9 Sept 2021

Miller Fredarla S, Crone Kathryn K, Jensen Matthew R, Shaw Sudipta, Harcombe William R, Elias Mikael H, Freeman Michael F

Abstract excerpt

Peptide backbone α-N-methylations change the physicochemical properties of amide bonds to provide structural constraints and other favorable characteristics including biological membrane permeability to peptides. Borosin natural product pathways are the only known ribosomally encoded and posttranslationally modified peptides (RiPPs) pathways to incorporate backbone α-N-methylations on translated peptides. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34504067
DOI: 10.1038/s41467-021-25575-7
PMCID: PMC8429565

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