Article

Upstream proteolysis by Ste24 does not require a C-terminal methyl ester as revealed using 33-residue a-factor precursor peptide substrates synthesized via epimerization-free methods

2024-11-29

Abstract excerpt

<title>Abstract</title> <p>Protein prenylation is a post-translational modification that links a specific cytosolic protein with a hydrophobic isoprenoid lipid resulting in membrane localization of the target protein. Following prenylation, some proteins undergo proteolytic removal of a C-terminal tripeptide. This step results in a protein terminating in a prenylcysteine residue that is subsequently methylated by...

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Literature Corpus work: db3a3256-6351-5e15-9907-8df97cd09fba
DOI: 10.21203/rs.3.rs-5094096/v1

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