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Article

Polygenic risk scores: pleiotropy and the effect of environment.

GeroScience - 1 Dec 2020

Loika Yury, Irincheeva Irina, Culminskaya Irina, Nazarian Alireza, Kulminski Alexander M

Abstract excerpt

Polygenic risk scores (PRSs) discriminate trait risks better than single genetic markers because they aggregate the effects of risk alleles from multiple genetic loci. Constructing pleiotropic PRSs and understanding heterogeneity, and the replication of PRS-trait associations can strengthen its applications. By using variational Bayesian multivariate high-dimensional regression, we constructed pleiotropic PRSs...

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PMID: 32488673
DOI: 10.1007/s11357-020-00203-2
PMCID: PMC7732954

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