Article
Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.
Circulation - 16 Apr 2002
Suzuki Miwako, Carlson Kerri M, Marchuk Douglas A, Rockman Howard A
Abstract excerpt
BACKGROUND: Understanding the role for genetic factors in human heart failure is difficult because environmental factors cannot be standardized and genetic variation is great. One approach to identify genes that modify disease outcome is to use mouse models that show strong genetic variation of the disease phenotype. METHODS AND RESULTS: In this study, we used transgenic mice that develop severe dilated...
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