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Article

Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus.

Life science alliance - 1 Jul 2020

Hortschansky Peter, Misslinger Matthias, Mörl Jasmin, Gsaller Fabio, Bromley Michael J, Brakhage Axel A, Groll Michael, Haas Hubertus, Huber Eva M

Abstract excerpt

Azoles are first-line therapeutics for human and plant fungal infections, but their broad use has promoted the development of resistances. Recently, a pan-azole-resistant clinical Aspergillus fumigatus isolate was identified to carry the mutation P88L in subunit HapE of the CCAAT-binding complex (CBC), a conserved eukaryotic transcription factor. Here, we define the mechanistic basis for resistance in this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32467317
DOI: 10.26508/lsa.202000729
PMCID: PMC7266990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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