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Article

Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2020

Mitchell Kimberly, Zhang Wo Su, Lu Chunyu, Tao Binbin, Chen Lu, Hu Wei, Trudeau Vance L

Abstract excerpt

The luteinizing hormone surge is essential for fertility as it triggers ovulation in females and sperm release in males. We previously reported that secretoneurin-a, a neuropeptide derived from the processing of secretogranin-2a (Scg2a), stimulates luteinizing hormone release, suggesting a role in reproduction. Here we provide evidence that mutation of the scg2a and scg2b genes using TALENs in zebrafish reduces...

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Identifiers

PMID: 32467166
DOI: 10.1073/pnas.2002004117
PMCID: PMC7293709

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