Article
PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.
Molecular and cellular endocrinology - 25 Sept 2012
Meelkop Ellen, Temmerman Liesbet, Janssen Tom, Suetens Nick, Beets Isabel, Van Rompay Liesbeth, Shanmugam Nilesh, Husson Steven J, Schoofs Liliane
Abstract excerpt
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying....
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