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Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish

3 Jan 2017

Abstract excerpt

It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hypothalamic control of reproductive hormones
Share to Reproductive biology and impacts on aquatic species

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PMID: 28359084
DOI: 10.1210/en.2016-1540

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