Article

Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior

2018-08-31

Abstract excerpt

Successful sexual reproduction involves complex, genetically encoded interplay between animal physiology and behavior. The rat provides a highly fecund mammalian model for studying how the brain impacts reproduction. Here, we report a forward genetics screen in rats to identify genes that affect reproduction. A panel of 18 distinct rat strains harboring Sleeping Beauty gene trap mutations were analyzed for the ab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e0f5905-2880-5533-a087-90bdbab75c21
DOI: 10.1101/405985

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behaviorDOI 10.1101/405985Read

Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulantsSemantic proximity Read

Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations.Semantic proximity Read

Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF.Semantic proximity Read

Magel2 truncation alters select behavioral and physiological outcomes in a rat model of Schaaf-Yang syndrome.Semantic proximity Read

A truncating mutation of <i>Magel2</i> in the rat modelled for the study of Schaaf-Yang and Prader-Willi syndromes alters select behavioral and physiological outcomesSemantic proximity Read

A patient-derived mouse model reproduces molecular, neurological, and sleep symptoms of SHINE syndrome.Semantic proximity Read

Germline Nuclear-predominant Pten Murine Model Exhibits Impaired Social and Perseverative Behavior, Microglial Activation, and Increased Oxytocinergic ActivitySemantic proximity Read

<i>Sry</i> -modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and moreSemantic proximity Read

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.Semantic proximity Read

Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.Semantic proximity Read

Sex chromosome complement regulates expression of mood-related genesSemantic proximity Read

Bazedoxifene rescues sexually dimorphic autistic-like abnormalities in mice carrying a biallelic <i>MDGA1</i> mutationSemantic proximity Read