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Article

Targeted Mutagenesis of the Hypophysiotropic Gnrh3 in Zebrafish (Danio rerio) Reveals No Effects on Reproductive Performance.

PloS one - 1 Jan 2016

Spicer Olivia Smith, Wong Ten-Tsao, Zmora Nilli, Zohar Yonathan

Abstract excerpt

Gnrh is the major neuropeptide regulator of vertebrate reproduction, triggering a cascade of events in the pituitary-gonadal axis that result in reproductive competence. Previous research in mice and humans has demonstrated that Gnrh/GNRH null mutations result in hypogonadotropic hypogonadism and infertility. The goal of this study was to eliminate gnrh3 (the hypophysiotropic Gnrh form) function in zebrafish...

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Identifiers

PMID: 27355207
DOI: 10.1371/journal.pone.0158141
PMCID: PMC4927163

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