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Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab Library

1 Sept 2017

Abstract excerpt

colonies) from the lymphocytes of 809 human donors, assessed available diversities of the heavy-chain variable (VH) and κ light-chain variable (VK) domain repertoires, and validated the library by selecting Fabs against 10 therapeutically relevant antigens by phage display. We obtained a database of unique 7,373 VH and 41,804 VK sequences by 454 pyrosequencing, and analyzed the repertoires. The distribution of VH...

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PMID: 28927259
DOI: 10.14348/molcells.2017.0106

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