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Article

A Gilbert syndrome-associated haplotype protects against fatty liver disease in humanized transgenic mice.

Scientific reports - 26 May 2020

Landerer Steffen, Kalthoff Sandra, Paulusch Stefan, Strassburg Christian P

Abstract excerpt

UDP-glucuronosyltransferases 1 A (UGT1A) enzymes are capable of detoxifying a broad range of endo- and xenobiotic compounds, which contributes to antioxidative effects, modulation of inflammation and cytoprotection. In the presence of low-function genetic UGT1A variants fibrosis development is increased in various diseases. This study aimed to examine the role of common UGT1A polymorphisms in NASH. Therefore,...

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Identifiers

PMID: 32457304
DOI: 10.1038/s41598-020-65481-4
PMCID: PMC7250928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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