Article
Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease.
Pediatrics - 1 Dec 2009
Lin Yu-Cheng, Chang Pi-Feng, Hu Fu-Chang, Chang Mei-Hwei, Ni Yen-Hsuan
Abstract excerpt
OBJECTIVE: Oxidative stress is increased in nonalcoholic fatty liver disease (NAFLD). Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant. We hypothesize that variant UGT1A1 genotypes reduce the risk for NAFLD development. METHODS: Two hun...
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