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Article

The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia

1 Mar 2000

Abstract excerpt

A major problem in the treatment of leukemia is the development of resistance to chemotherapeutic agents. There are several ways for cancer cells to develop resistance or defense mechanisms against cytotoxic drugs. This review paper will focus on membrane transport-associated multidrug resistance (MDR). The proteins involved, P-glycoprotein (P-gp), MRP1 and LRP/MVP, share the ability to act as drug transport...

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PMID: 10739113
DOI: 10.5414/cpp38094

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