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Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies

25 Jun 2004

Abstract excerpt

The multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), and the multidrug resistance-related proteins (MRPs) are members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter gene superfamily that regulates the trafficking of drugs, peptides, ions, and xenobiotics across cell membrane barriers. Three-dimensional modeling of human MDR1/P-gp indicates that these glycoproteins...

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PMID: 15217827
DOI: 10.1182/blood-2003-07-2490

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