EGFR-mutated lung adenocarcinomas from patients who progressed on EGFR-inhibitors show high engraftment rates in xenograft models.

doi:10.1016/j.lungcan.2020.03.022

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Article

EGFR-mutated lung adenocarcinomas from patients who progressed on EGFR-inhibitors show high engraftment rates in xenograft models.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2020

Martins-Filho Sebastiao N, Weiss Jessica, Pham Nhu-An, Li Quan, Cabanero Michael, Fares Aline, Stewart Erin L, Shi Ruoshi, Patel Devalben, Pal Prodipto, McConnell Judy, Bradbury Penelope Ann, Sacher Adrian G, Leighl Natasha B, Grindlay Alexandria, Allison Frances, Li Ming, Yasufuku Kazuhiro, Shepherd Frances A, Moghal Nadeem, Tsao Ming-Sound, Liu Geoffrey

Abstract excerpt

OBJECTIVE: Patient-derived xenografts (PDX) are useful preclinical models to study cancer biology and mechanisms of drug response/resistance, particularly in molecularly targetable tumors. However, PDX engraftment may not be stochastic. We investigated clinical, histological and molecular features associated with PDX engraftment in a large cohort of EGFR-mutated lung adenocarcinoma (LUAD). MATERIAL AND METHODS:...

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PMID: 32447118
DOI: 10.1016/j.lungcan.2020.03.022

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