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Article

Clinical and pathological predictors of engraftment for patient-derived xenografts in lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2024

Ogawa Hiroyuki, Koga Takamasa, Pham Nhu-An, Bernards Nicholas, Gregor Alexander, Sata Yuki, Kitazawa Shinsuke, Hiraishi Yoshihisa, Ishiwata Tsukasa, Aragaki Masato, Yokote Fumi, Effat Andrew, Kazlovich Kate, Li Quan, Hueniken Katrina, Li Ming, Maniwa Yoshimasa, Tsao Ming-Sound, Yasufuku Kazuhiro

Abstract excerpt

Patient-derived xenografts (PDXs) are increasingly utilized in preclinical drug efficacy studies due to their ability to retain the molecular, histological, and drug response characteristics of patient tumors. This study aimed to investigate the factors influencing the successful engraftment of PDXs. Lung adenocarcinoma PDXs were established using freshly resected tumor tissues obtained through surgery....

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Identifiers

PMID: 38968761
DOI: 10.1016/j.lungcan.2024.107863

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KRAS
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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