An association between successful engraftment of osteosarcoma patient-derived xenografts and clinicopathological findings.

doi:10.14670/HH-18-256

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Article

An association between successful engraftment of osteosarcoma patient-derived xenografts and clinicopathological findings.

Histology and histopathology - 1 Nov 2020

Fortuna-Costa Anneliese, Granato Regina Alcantara, Meohas Walter, Lopes Ana Cristina de Sá, Caruso Anabela Cunha, Castro E Silva Pinheiro Rafael, d'Eça Pedro da Gama, Dias Rhayra Braga, Perini Jamila Alessandra, Barbosa Ana Paula Fernandes, Moreira de Sá Renato Augusto, Guimarães João Antonio Matheus, Murray Samuel S, Duarte Maria Eugenia Leite

Abstract excerpt

Although osteosarcoma is a rare disease, with a global incidence rate estimated at 5.0/million/year, it is the most frequent primary bone sarcoma in children and adolescents. In translational research, the patient-derived xenograft (PDX) model is considered an authentic in vivo model for several types of cancer, as tumorgrafts faithfully retain the biological characteristics of the primary tumors. Our goal was to...

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PMID: 32964941
DOI: 10.14670/HH-18-256

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