Article
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
Blood advances - 26 May 2020
Lewis Natasha E, Petrova-Drus Kseniya, Huet Sarah, Epstein-Peterson Zachary D, Gao Qi, Sigler Allison E, Baik Jeeyeon, Ozkaya Neval, Moskowitz Alison J, Kumar Anita, Horwitz Steven M, Zhang Yanming, Arcila Maria E, Levine Ross L, Roshal Mikhail, Dogan Ahmet, Xiao Wenbin
Abstract excerpt
TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry-sorted bone marrow and peripheral blood...
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