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Article

Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.

Development (Cambridge, England) - 22 Jun 2020

Brandt Zachary J, Echert Ashley E, Bostrom Jonathan R, North Paula N, Link Brian A

Abstract excerpt

The development of the biliary system is a complex yet poorly understood process, with relevance to multiple diseases, including biliary atresia, choledochal cysts and gallbladder agenesis. We present here a crucial role for Hippo-Yap/Taz signaling in this context. Analysis of sav1 mutant zebrafish revealed dysplastic morphology and expansion of both intrahepatic and extrahepatic biliary cells, and ultimately...

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Identifiers

PMID: 32439761
DOI: 10.1242/dev.184242
PMCID: PMC7328147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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