Article

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

2020-09-10

Abstract excerpt

Polycystic liver disease (PLD) is characterized by the growth of numerous biliary cysts and presents in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), causing significant morbidity. Interestingly, deletion of intraflagellar transport-B (IFT-B) genes in adult mouse models of ADPKD attenuates severity of PKD and PLD. Here we examine the role of deletion of IFT-A gene, Thm1 , in PLD of juvenile...

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Literature Corpus work: 366ed509-544a-5651-ba73-88e2be0fa6ff
DOI: 10.1101/2020.09.10.289645

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