Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.

doi:10.1016/j.celrep.2021.109310

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Article

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.

Cell reports - 6 Jul 2021

Molina Laura M, Zhu Junjie, Li Qin, Pradhan-Sundd Tirthadipa, Krutsenko Yekaterina, Sayed Khaled, Jenkins Nathaniel, Vats Ravi, Bhushan Bharat, Ko Sungjin, Hu Shikai, Poddar Minakshi, Singh Sucha, Tao Junyan, Sundd Prithu, Singhi Aatur, Watkins Simon, Ma Xiaochao, Benos Panayiotis V, Feranchak Andrew, Michalopoulos George, Nejak-Bowen Kari, Watson Alan, Bell Aaron, Monga Satdarshan P

Abstract excerpt

Yes-associated protein 1 (YAP1) regulates cell plasticity during liver injury, regeneration, and cancer, but its role in liver development is unknown. We detect YAP1 activity in biliary cells and in cells at the hepatobiliary bifurcation in single-cell RNA sequencing analysis of developing livers. Deletion of Yap1 in hepatoblasts does not impair Notch-driven SOX9+ ductal plate formation but does prevent the...

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Identifiers

PMID: 34233187
DOI: 10.1016/j.celrep.2021.109310
PMCID: PMC8280534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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