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Article

The strength of transcription-factor binding modulates co-variation in transcriptional networks.

Trends in genetics : TIG - 1 Feb 2010

Nuzhdin Sergey V, Rychkova Anna, Hahn Matthew W

Abstract excerpt

An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the strength of DNA binding for individual TFs translates into regulatory control, or whether a different set of...

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Identifiers

PMID: 20080313
DOI: 10.1016/j.tig.2009.12.005
PMCID: PMC2826431

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