Article
Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis.
BMC genomics - 5 Feb 2018
Ruesen Carolien, Chaidir Lidya, van Laarhoven Arjan, Dian Sofiati, Ganiem Ahmad Rizal, Nebenzahl-Guimaraes Hanna, Huynen Martijn A, Alisjahbana Bachti, Dutilh Bas E, van Crevel Reinout
Abstract excerpt
BACKGROUND: Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant. METHODS: We whole-genome sequenced M. tuberculosis strains isolated from 322 HIV-negative tuberculosis patients from Indonesia and compared isolates from...
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