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Article

Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2016

Westeneng Henk-Jan, Walhout Renée, Straathof Milou, Schmidt Ruben, Hendrikse Jeroen, Veldink Jan H, van den Heuvel Martijn P, van den Berg Leonard H

Abstract excerpt

BACKGROUND: In patients with a C9orf72 repeat expansion (C9+), a neuroimaging phenotype with widespread structural cerebral changes has been found. We aimed to investigate the specificity of this neuroimaging phenotype in patients with amyotrophic lateral sclerosis (ALS). METHODS: 156 C9- and 14 C9+ patients with ALS underwent high-resolution T1-weighted MRI; a subset (n=126) underwent diffusion-weighted imaging....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27756805
DOI: 10.1136/jnnp-2016-313959
PMCID: PMC5136726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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