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Article

Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Villares Gabriel J, Zigler Maya, Dobroff Andrey S, Wang Hua, Song Renduo, Melnikova Vladislava O, Huang Li, Braeuer Russell R, Bar-Eli Menashe

Abstract excerpt

The thrombin receptor protease activated receptor-1 (PAR-1) is overexpressed in metastatic melanoma cell lines and tumor specimens. Previously, we demonstrated a significant reduction in tumor growth and experimental lung metastasis after PAR-1 silencing via systemic delivery of siRNA encapsulate...

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Source

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Identifiers

PMID: 21187389
DOI: 10.1073/pnas.1006886108
PMCID: PMC3021062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21187389-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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