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Article

PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma.

Oncogene - 8 Jun 2017

Delyon J, Servy A, Laugier F, André J, Ortonne N, Battistella M, Mourah S, Bensussan A, Lebbé C, Dumaz N

Abstract excerpt

The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway by PDE type 4 (PDE4) favors tumor progression. For example, in melanomas harboring RAS mutations, the overexpression of PDE4 is crucial for MAPK pathway...

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Topics

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Share to Cell Movement
Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 1

Share to Melanocytes

Share to Melanoma

Share to Neoplasm Invasiveness

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 28092671
DOI: 10.1038/onc.2016.469

Genes

BRAF
RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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